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Application of Electrospun Nanofibrous PHBV Scaffold in Neural Graft and Regeneration: A Mini-Review

Among the synthetic polymers, poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microbial polyester is one of the biocompatible and biodegradable copolymers in the nanomedicine scope.

Abstract

Among the synthetic polymers, poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microbial polyester is one of the biocompatible and biodegradable copolymers in the nanomedicine scope. PHBV has key points and suitable properties to support cellular adhesion, proliferation and differentiation of nanofibers. Nanofibers are noticeably employed in order to enhance the performance of biomaterials, and could be effectively considered in this scope. Electrospinning is one of the well-known and practical methods that extremely employed in the construction of nanofibrous scaffolds for biomedical application and recently PHBV has exploited in nerve graft and regenerative medicine. PHBV composites nanofibrous scaffolds are able to be applied as promising materials in many fields, such as; wound healing and dressingtissue engineering, targeted drug delivery systems, functional carries, biosensors or nano-biosensors and so on. In this mini-review, we attempt to provide a more detailed overview of the recent advances of PHBV electrospun nanofibers application in neural graft and regeneration.

Article 7Volume 1, Issue 2, Autumn 2016, Page 107-111   PDF (421 K) Document Type: Mini Review Paper DOI: 10.7508/nmrj.2016.02.007
 

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Investigation of acute dermal irritation/corrosion, acute inhalation toxicity and cytotoxicity tests for Nanobiocide®

Article 4Volume 1, Issue 1, Summer 2016, Page 23-29  XMLPDF (1029 K)
Document Type: Original Research Article
DOI: 10.7508/nmrj.2016.01.004
Authors
Mansour Hemmati1Ali Ghasemzadeh This email address is being protected from spambots. You need JavaScript enabled to view it. 2Mohammad Haji Malek-kheili2Kamyar Khoshnevisan13Mohammad Kazem Koohi4
1Nano Pooshesh Felez co, University of Tehran Science and Technology Park, Tehran, Iran
2Iran Nanohealth Committee, Ministry of Health and Medical Education, Food and Drug Administration, Tehran, Iran
3Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
4Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Abstract

Objective(s): Nanomaterials, especially silver Nanoparticles (Ag-NPs), are employed in an increasing number of commercial products. This has led to an ever growing exposure of human beings to this substance. The first purpose of the Nano Committee of Food and Drug Administration of The Islamic Republic of Iran (IFDA) is developing guidelines to assess and approve commercial nano-health products for their safety of human applications. Nanobiocide® as a commercial product of stable colloid including 2000 ppm Ag-NPs for surface antimicrobial applications was investigated according to IFDA guidelines in the approval process. 

Methods: The first fabrication and characterization method of the product were determined. The human exposure to Nanobiocide® were studied by cytotoxicity assay, dermal irritation and inhalation toxicity assay based on the standard assay. 

Results: According to cytotoxicity assay by MTT method the concentration-dependent of cell viability was reduced and Inhibitory concentration-50 was about 1160 ppm. The Draize dermal irritation scoring system (DDIS) showed no irritation to the skin of rabbits. No sign of gross toxicity, adverse pharmacological effect, or abnormal behavior based on inhalation toxicity was observed. 

Conclusions: The consideration of toxicity of Nanobiocide® is one of the major key for medical application. The results obtained revealed that the Nanobiocide® may be safe using in domestic and veterinary applications.
Keywords
Nanobiocide®Commercial productCytotoxicity assayInhalation toxicity