Nanocelluloses, a way to get rid of chemotherapy problems
Nanocelluloses, a way to get rid of chemotherapy problems
Cancer is one of the leading causes of death worldwide, affecting millions of people every year. Although chemotherapy remains one of the most common cancer treatments in the world, the severe side effects of chemotherapy drugs impose serious concerns to cancer patients.Targeted delivery of these drugs to the tumor site increases their effectiveness. However, excess drugs can still circulate in the rest of the body and cause numerous side effects, including anemia, chronic infections, hair loss, jaundice, and fever. A biopolymer is a polymer made in nature by plants, animals, and microorganisms,are made through biochemical reactions. Such polymers can be decomposed and recycled. A group of these biopolymers are polysaccharides. Cellulose, which is a member of the polysaccharide family, is used as a biodegradable filler and reinforcement for thermoplastic and thermoplastic polymers. One of the ways to improve the properties of biopolymers is to convert them into nano-sized particles and use these nanomaterials as a reinforcing phase in composites. Nanocelluloses can be classified based on their sources and extraction methods. However, the main source of cellulose is plant fiber. But cellulose can be found in plants, animals, algae, fungi and minerals. Nanocellulose, in drug delivery systems and cancer treatments, causes good water permeability, antioxidant activity, biocompatibility, biodegradability and less or no toxicity, and this is an advantage compared to conventional chemotherapy drugs. Significant side effects of chemistry The treatment is diarrhea and damage to the mucous membrane of the digestive system, which should be dramatically reduced if new drug delivery systems such as nanocellulose are used. Nanocellulose as one of the new nanomaterials with high capabilities such as proper stability, chemical functionalization and control over surface interactions, high level, etc. is very significant and has found numerous and accessible applications. To reduce the off-target effects of anticancer drugs during chemotherapy, it is necessary to remove them from the circulation.Nanocrystal line cellulose (ENCC), bind to positively charged drugs in human serum and capture DOX immediately without imposing any cytotoxicity and hemolytic effects. The importance of this class of substances from a scientific point of view is due to the use of renewable and environmentally friendly raw materials, which has caused the vital movement of nanocelluloses development. Nanocelluloses can be considered supermaterials. future ones that will create a tremendous transformation in various industries, especially healthcare.
Reference:
Wijaya, C. J., Ismadji, S., & Gunawan, S. (2021). A review of lignocellulosic-derived nanoparticles for drug delivery applications: lignin nanoparticles, xylan nanoparticles, and cellulose nanocrystals. Molecules, 26(3), 676.
Anirudhan, T. S., Manjusha, V., & Sekhar, V. C. (2021). A new biodegradable nano cellulose-based drug delivery system for pH-controlled delivery of curcumin. International Journal of Biological Macromolecules, 183, 2044-2054.
Gupta, B., Mishra, V., Gharat, S., Momin, M., & Omri, A. (2021). Cellulosic polymers for enhancing drug bioavailability in ocular drug delivery systems. Pharmaceuticals, 14(11), 1201.
Karimian, A., Parsian, H., Majidinia, M., Rahimi, M., Mir, S. M., Kafil, H. S., … & Yousefi, B. (2019). Nanocrystalline cellulose: Preparation, physicochemical properties, and applications in drug delivery systems. International journal of biological macromolecules, 133, 850-859.
Khine, Y. Y., & Stenzel, M. H. (2020). Surface modified cellulose nanomaterials: a source of non-spherical nanoparticles for drug delivery. Materials Horizons, 7(7), 1727-1758.
Young, S. A., Muthami, J., Pitcher, M., Antovski, P., Wamea, P., Murphy, R. D., … & Sheikhi, A. (2022). Engineering hairy cellulose nanocrystals for chemotherapy drug capture. Materials Today Chemistry, 23, 100711.
Preparation and editing of news:
Dr. Mercedeh Fateme Yazdan Bakhsh
Chairman of the Board of Directors at Aytin Najo Cellulose Nita Company (Special Shares)
Lecturer and consultant of applied scientific center of Jihad University of Karaj
